RECOVER: AN AUTOMATED, CLOUD-BASED DECISION SUPPORT SYSTEM FOR POST-FIRE REHABILITATION PLANNING




Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide

Temozolomide (TMZ), a DNA methylating agent, is the primary chemotherapeutic drug used in glioblastoma treatment.TMZ induces mostly N-alkylation adducts (N7-methylguanine and N3-methyladenine) and some O6-methylguanine (O6mG) adducts.Current models propose that during DNA replication, thymine is incorporated across from O6mG, promoting a futile cyc

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